High Prevalence of Secondary Hyperparathyroidism in Patients Under Regular Hemodialysis in Brack-Alshati General hospital

Aisha Faddel (1) , Mabroukah Alzwayi (1) , Nasser Alaswaad (1)
(1) Medical Laboratory Science Department, Faculty of Engineering and Technology, Sebha University, Brack-Alshati, Libya

Abstract

Secondary hyperparathyroidism is a common complication of chronic kidney disease. We estimated serum parathyroid hormone and some minerals in 46 patients undergoing hemodialysis treatment in the dialysis center at Brack Alshati General Hospital during September 2021 to October 2021. Before dialysis, a blood sample was collected for assessment of PTH level and minerals, including calcium, phosphorus, sodium, and potassium. The mean age of the patients was 45.37±17.14 years. The mean concentration of PTH for the study group was 826.77 ± 646.86 pg/ml. The prevalence of secondary hyperparathyroidism (SHPT) among the patients was 73.91%. We conclude that SHPT is highly prevalent in our hemodialysis population and has serious outcomes for the health of patients. If it is poorly overcome, this imbalance can result in the bone disease, calcification of soft tissue, and vascular calcification; all of these are found to be influential on mortality and morbidity.

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References

[1]-Levey, A.S., et al., Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).Kidney international, 2005. 67(6): p. 2089-2100.

[2]-Chen, T.K., D.H. Knicely, and M.E. Grams, Chronic kidney disease diagnosis and management: a review.Jama, 2019. 322(13): p. 1294-1304.

[3]-Cotoi, L., et al., Thyroid Pathology in End-Stage Renal Disease Patients on Hemodialysis.Diagnostics, 2020. 10(4): p. 245.

[4]-Li, J., et al., Correlates of parathyroid hormone concentration in hemodialysis patients.Nephrology Dialysis Transplantation, 2013. 28(6): p. 1516-1525.

[5]-Kovesdy, C., et al., Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease.Kidney international, 2008. 73(11): p. 1296-1302.

[6]-Cozzolino, M., et al., Parathyroid Glands in CKD: Anatomy, Histology, Physiology and Molecular Biology in CKD, in Parathyroid Glands in Chronic Kidney Disease. 2020, Springer. p. 1-19.

[7]-Tomasello, S., Secondary hyperparathyroidism and chronic kidney disease.Diabetes Spectrum, 2008. 21(1): p. 19-25.

[8]-Gimba, Z.M., et al., Secondary hyperparathyroidism among Nigerians with chronic kidney disease.African health sciences, 2018. 18(2): p. 446-457.

[9]-Ahmed, H.A., et al., Prevalence of mineral bone disorders among hemodialysis patients in Menoufia Governorate, Egypt.Menoufia Medical Journal, 2017. 30(3): p. 687.

[10]-Zhou, X., Y. Guo, and Y. Luo, The optimal range of serum intact parathyroid hormone for a lower risk of mortality in the incident hemodialysis patients.Renal failure, 2021. 43(1): p. 599-605.

[11]-Fathima, R., & Rao, C. U. (2021). Study of the Prevalence and Severity of Disordered Mineral Metabolism in Patients with Chronic Kidney Disease Stage-5 on Hemodialysis.Journal of Contemporary Medicine and Dentistry, 2021. 9(2): p. 8-12

[12]-Owda, A., et al., Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race.Renal failure, 2003. 25(4): p. 595-602.

[13]-Mahmoud, M., N.A.E. Zaki, and A.T. Ali, Study of hyperparathyroidism among patients with chronic kidney disease at sohag university hospital.Sohag Medical Journal, 2017. 21(3): p. 367-380.

[14]-Wei, J. H., Lee, W. J., Chong, K., Lee, Y. C., Chen, S. C., Huang, P. H., & Lin, S. J. (2018). High incidence of secondary hyperparathyroidism in bariatric patients: comparing different procedures.Obesity surgery,28(3), 798-804.

[15]-Xu, Y., et al., Secondary hyperparathyroidism and adverse health outcomes in adults with chronic kidney disease. Clinical Kidney Journal, 2021

[16]-14.Arora, K., et al., Correlation of parathyroid hormone levels with mineral status in end-stage renal disease patients.Indian journal of endocrinology and metabolism, 2018. 22(6): p. 735.

[17]-Abdelgader, N.I. and A. Abdrabo, Serum calcium, phosphorous, and parathyroid hormone in Sudanese patients under regular haemodialysis.American Journal of Research Communication, 2013. 1(12): p. 353-359.

[18]-Silver, J., R. Kilav, and T. Naveh-Many, Mechanisms of secondary hyperparathyroidism. American Journal of Physiology-Renal Physiology, 2002. 283(3): p. F367-F376

[19]-Rahimian, M., R. Sami, and F. Behzad, Evaluation of secondary hyperparathyroidism in patients undergoing hemodialysis.Saudi Journal of Kidney Diseases and Transplantation, 2008. 19(1): p. 116.

[20]-Owiredu, W., et al., Relationship between parathyroid hormone and electrolytes in chronic kidney disease.E3 Journal of Medical Research, 2012. 1(8): p. 103-111.

[21]-Jannot, M., et al., Evolution of secondary hyperparathyroidism in patients following return to hemodialysis after kidney transplant failure.Nephrologie & therapeutique, 2020. 16(2): p. 118-123.

[22]-Cantor T, Sci B. The assay of the hypocalcemic PTH fragment inhibitor with PTH provides a more accurate assessment of renal osteodystrophy compared to the intact PTH assay. Nefrologia 2003;23:69-72.

[23]-21.KOVESDY, C., AHMADZADEH, S., ANDERSON, J. & KALANTAR-ZADEH, K. 2008. Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease. Kidney international, 73, 1296-1302.

[24]-FUJII, H. 2018. Association between parathyroid hormone and cardiovascular disease. Therapeutic Apheresis and Dialysis,22,236-241.

Authors

Aisha Faddel
[email protected] (Primary Contact)
Mabroukah Alzwayi
Nasser Alaswaad
Faddel, A., Alzwayi, M., & Alaswaad, N. (2022). High Prevalence of Secondary Hyperparathyroidism in Patients Under Regular Hemodialysis in Brack-Alshati General hospital. Journal of Pure & Applied Sciences , 21(3), 30-33. https://doi.org/10.51984/jopas.v21i3.2396

Article Details

How to Cite

Faddel, A., Alzwayi, M., & Alaswaad, N. (2022). High Prevalence of Secondary Hyperparathyroidism in Patients Under Regular Hemodialysis in Brack-Alshati General hospital. Journal of Pure & Applied Sciences , 21(3), 30-33. https://doi.org/10.51984/jopas.v21i3.2396

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