The Possible Role of Prostaglandins in Regulation of the Intra-ocular Pressure and the Value of Electro-retinography in Long Term Pressure Control

Ali A. Elzarga; Gergess S. Youssef

المؤلفون

Ali A. Elzarga Departments of Ophthalmology and Medical Physiology, Sirte and Menoufeya Universities, Libya & Egypt
Gergess S. Youssef Departments of Ophthalmology and Medical Physiology, Sirte and Menoufeya Universities, Libya & Egypt

الكلمات المفتاحية:

Glaucoma، Intra-ocular pressure، Prostaglandin analogues، Latanoprost، Electroretinography، Visual evoked potentials

الملخص

Editorial summary prepared for the online archive; the original print article was published without an abstract.

Background: Glaucoma is a leading cause of blindness in the Middle East. This study assessed the possible role of prostaglandins in regulating aqueous humour formation and the value of the electrical activity of the retina for monitoring the eye under raised intra-ocular pressure (IOP).

Methods: Thirty patients with open-angle glaucoma (OAG) attending the ophthalmology outpatient clinic of Ibn-Sina University Hospital, Sirte, Libya, were divided into three groups of 10: untreated, conventionally treated with acetazolamide and 0.5% timolol eye drops, and treated with latanoprost 0.005% eye drops for 4 weeks. They were compared with a control group of 10. IOP was measured weekly by pneumotonometry, and the electroretinogram (ERG) and visual evoked potentials (VEP) were recorded at the end of the fourth week.

Results: IOP was significantly raised in the untreated group throughout the study. Timolol significantly lowered IOP but did not restore it to control values, whereas latanoprost restored IOP to control values by the end of the fourth week. Untreated glaucoma markedly reduced the amplitude and duration of the ERG waves and of the VEP. Timolol produced only partial recovery of the ERG and did not restore the VEP, while latanoprost restored the ERG and VEP parameters to control values or above.

Conclusion: Prostaglandins may have a major role in regulating aqueous humour formation, and prostaglandin analogues such as latanoprost may be of greater value than conventional therapy for controlling IOP in OAG, with an additional retinoprotective effect. Recording the electrical activity of the retina may serve as a long-term tool for assessing the effect of raised IOP on the retina.

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