The Effect of Prostaglandins on Female Reproductive System
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Prostaglandins, The Female Reproductive System, Delivery, The Chemical Structure of Prostaglandins
Abstract
Prostaglandins are hormone-like substances produced in various mammalian tissues, mediating a wide range of physiological functions, and their metabolic compounds are found in virtually all organs and tissues (13). It plays an important role in the processes of reproduction and pregnancy. It affects the uterus' functions in the menstrual cycle, fetal implantation, pregnancy, and childbirth (9). The importance of (PG) lies in the very early stages of the development of the different vesicles before the emergence of the pituitary hormone receptors, and it helps stimulate the (FSH) receptors, and the (PG) may act in a manner similar to (LH) on the tika cells and helps to initiate the growth of the vesicle. And (PG) can be considered as factors of vesicular origin within the ovary to participate in controlling the growth of non-developing follicles with pituitary gonadotropin to become essential growth regulating factors, as they may capture LH and FSH receptors (2). The onset of menstruation immediately precedes constriction of small arterioles in Endumtrium. PG participates in this process through the action of (PGF2α) on these arterioles, and the contractile activity of myomatrium is significant during the menstrual period and this activity is associated with high concentrations of (PGF2α) at the same time with a decrease in the level of progesterone and it is known that progesterone inhibits the stimulating action of (PGF2α) on myomatrium. (9). The (PG) is involved in the rupture of the ovarian follicle (especially PGF2α) and the formation of (PG) increases during the period of ovulation, and this increase depends on the gonadotropin hormones (21). Important in all stages of pregnancy and fetal implantation, it enables tropoplast to invade and settle in the blood vessels in the myometrium in the womb of the mother at all stages of fetal growth and development, where it plays an important role as a vascular regulator of fetal uterine blood flow, and controls the beginning and progress of the birth process and its progress (9). Prostaglandins play an important role in contracting uterine muscles and stimulating labor (16).
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References
[1]-Andrew M. Blanksa, Steven Thorntonb. 2003. The role of oxytocin in parturition. BJOG: AnInternational Journal of Obstetrics and Gynaecology April 2003, Vol. 110 (Suppl 20), pp. 46–51.
[2]-David T. Armstrong.1981. Prostaglandins and follicular functions. Journals of Reproduction & Fertility Ltd.J. Reprod.Fert. 62,283-291.Printed in Pritain.
[3]-Downie, J.N. L. poyser and M. Wutnderlich. 1974. Levels ofprostaglandins inHuman Endometriumduring thenormal MenstrualCycle. J. Physiol. (1974), 236, pp. 465-472 465With 2 text-ftgure8 Printed in Great Britain. GLOWM The Global library of womenʼs medicine. Under review -Update due 2016.
[4]-Flower,R. J, 2006.Prostaglandins, bioassay and inflammation. British Journal of Pharmacol. 2006 Jan; 147(Suppl 1): S182–S192.
[5]-Funk CD. 2001. Prostaglandins and leukotrienes_ advances in eicosanoid biology.Reproductive Biology and Endocrinology.Reproductive Biology and Endocrinology.Journal ListReprod Biol Endocrinol.
[6]-Fortier, M.A., K. Krishnaswamy, G. Danyod, S. Boucher-Kovalik, P. ChapdelaineJ.A.2008. A postgenomic integratred view of Prostaglandinsin Reproduction: Implications for OtherOddy System. Jornal of Physiology and Pharmacology 2008.59, Supp l,1, 65-89www.jpp.krakow.pl.
[7]-Gillian M.CraigM.D., M.R.C.P.1975. Prostaglandins in reproductive physiology. Postgraduate Medical Journal (February 1975) 51, 74-84.
[8]-Glen Reid, Peter Wielinga, Noam Zelcer, Ingrid van der Heijden,Annemieke Kuil,Marcel de Haas, Jan Wijnholds, and Piet Borst†.2003. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs .Proceedings of the National Academy of Scienceswww.pnas.org.Current Issue vol. 100 no. 16.Contributed by Piet Borst, May 21, 2003.
[9]-Iliodromiti Zoe, Grigoriadis Charalampos, Stournaras Stamatis, Daniilidis Angelos, Dafopoulos Konstantinos, Vrachnis Nikolaos.2014. Placental eicosanoids as endocrine and paracrine mediators during pregnancy. HJOG ReviewanObstetrics and Gynecology International Journal.Volume 13, Issue 1, January -March 2014.
[10]-John R. G. Challis1, Deborah M. Sloboda1,3, Nadia Alfaidy1, StevenJ. Lye1, William Gibb1,2, Fal A. Patel1, Wendy L. Whittle1 and John P. Newnham.2002.Prostaglandins and mechanisms of preterm birth. Reproduction.124, 1–17. Society 1470for Reproduction and Fertility-1626/2002.
[11]-Jabbour, H.N. and K.J. Sales. 2004. Prostaglandin receptor signalling andfunction in human endometrial pathology. Trends inEndocrinology and Metabolism Vol.15 No.8 October.
[12]-Nelson, Randy F. (2005).An introduction to behavioral endocrinology (3rd ed.). Sunderland, Mass: Sinauer Associates. p.100.
[13]-K moore, P.1982. Prostaglandins, prostacyclin and Thromboxanes.BiochemicalEducation 10(3)1982.
[14]-Mohan Singh, Parvesh Chaudhry and Eric Asselin. 2011. Bridging endometrial receptivity and implantation: network ofhormones, cytokines, and growth factors. Journal of Endocrinology 210, 5–14.
[15]-Murray D. Mitchell.1992. Biochemistry of the prostaglandins. Baillibre's Clinical Obstetrics and Gynaecology-Vol. 6, No. 4, December,ISBN 0-7020-1694-2.
[16]-Scott W. Walsh, PhD.2011. Prostaglandins in Pregnancy.GLOWM The Global library of womenʼs medicine. Under review -Update due 2016.
[17]-Kenneth E. Clark, PhD.2008. Prostaglandins and the Reproductive Cycle. GLOWM The Global library of womenʼs medicine.Under review -Update due 2016.
[18]-Sandra P. Welch, Ph.D. The Arachidonic Acid Cascade.2001. ProfessorPharmacology & Toxicology Smith.
[19]-Sheikh Arshad Saeed, Zia-ur-rehman Qureshi, AsmaSalim, JaveriaQuadri.2008. Prostaglandins and Cytokines in pregnancy and labor.J.Chem.soc.pak., vol.30, No.6,2008.
[20]-Solvo Biotechnology.2016. MRP4 Transporter (Multidrug resistance-associated protein 4/ABCC4),2016 -All rights reserved.
[21]-Tony G. Zreik, MD.Harold R. Behrman. 2016.The Prostaglandins BasicChemistry and Action _ GLOWM The Global library of womenʼs medicine. Under review -Update due 201.
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