Spectrophotometric method for the determination of Colchicine in pure and pharmaceutical forms (A Kinetic Study)
Article Sidebar
Deprecated: Return type of Carbon\Carbon::createFromTimestamp($timestamp, $tz = null) should either be compatible with DateTime::createFromTimestamp(int|float $timestamp): static, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/sebha/public_html/journal/lib/pkp/lib/vendor/nesbot/carbon/src/Carbon/Traits/Timestamp.php on line 29
February 13, 2020
-
Colchicine, Chemical kinetics, Oxidation, Permanganate, Spectrophotometry
Abstract
Simple, rapid spectrophotometric method for the determination of colchicine in pure as well as in dosage form is described. This method was based on oxidation of colchicine by alkaline potassium permanganate at room temperature. Under the optimized reaction conditions, Beer’s law correlating the absorbance with colchicine concentration was obeyed in the range of 4-20 ?gml-1. The absorbance was measured at ?max 433, 524, and 610 nm. The calibration graph was linear over these concentrations. The limits of detection were 2.33, 5.83 and 2.86 µgml?¹, respectively. The stoichiometry of the reaction was studied. The method was successfully applied to the determination of colchicine in its pharmaceutical tablets, with high-quality accuracy and precisions.
Full text article
References
[1] Wen, W., Tan, Yumei, Xiong, Huayu, & Wang, Shengfu. (2010). Voltammetric and spectroscopic investigations of the interaction between colchicine and bovine serum albumin. International Journal of Electrochemical Science, 5, 232–241.
[2] Gowda, B. G. (2014). High-performance liquid chromatographic determination of colchicine in pharmaceutical formulations and biological fluids. International Journal of Pharmacy and Pharmaceutical Sciences, 6, 335–337.
[3] Chandrethiya, G. D., Shelat, P. K., & Zaveri, M. N. (2013). RP-HPLC method development and validation for estimation of colchicine in gelatin nanoparticles formulation. International Journal of Pharmacy and Pharmaceutical Sciences, 5(1), 228–231.
[4] Leung, Y. Y., Hui, L. L. Y., & Kraus, V. B. (2015). Colchicine—Update on mechanisms of action and therapeutic uses. Seminars in Arthritis and Rheumatism. Elsevier.
[5] Sarg, T. M., El-Domiaty, M. M., Bishr, M. M., Salama, O. M., & El-Domiaty Gindy, A. R. (1989). Thin-layer chromatographic scanner, spectrophotometric and high-performance liquid chromatographic methods for the determination of colchicine. Analyst, 114(5), 575–578.
[6] Tracqui, A., Kintz, P., Ludes, B., Rouge, C., Douibi, H., & Mangin, P. (1996). High-performance liquid chromatography coupled to ion spray mass spectrometry for the determination of colchicine at ppb levels in human biofluids. Journal of Chromatography B: Biomedical Sciences and Applications, 675(2), 235–242.
[7] Alali, F., Tawaha, K., & Qasaymeh, R. M. (2004). Determination of colchicine in Colchicum steveni and C. hierosolymitanum (Colchicaceae): Comparison between two analytical methods. Phytochemical Analysis, 15(1), 27–29.
[8] Bodoki, E., Oprean, R., Vlase, L., Tamas, M., & Sandulescu, R. (2005). Fast determination of colchicine by TLC-densitometry from pharmaceuticals and vegetal extracts. Journal of Pharmaceutical and Biomedical Analysis, 37(5), 971–977.
[9] Hamscher, G., Priess, B., Nau, H., & Panariti, E. (2005). Determination of colchicine residues in sheep serum and milk using high-performance liquid chromatography combined with electrospray ionization ion trap tandem mass spectrometry. Analytical Chemistry, 77(8), 2421–2425.
[10] Nikhil, S., Praveen, P., Darshan, D., & Kamlesh, D. (2012). A validated HPTLC method for determination of colchicine in Gloriosa superba collected from different regions of India. Journal of Pharmacy Research, 5(7), 3858–3859.
[11] Nirmala, K., & Raju, R. R. (2012). A novel method development for validation and detection of colchicine drug by RP-HPLC. Rasayan Journal of Chemistry, 5, 106–111.
[12] Maslarska, V., & Pencheva, I. (2014). Determination of colchicine content in drug by RF-HPLC. International Journal of Advances in Pharmacy, Biology and Chemistry, 3, 116–119.
[13] Turk, W., & Olimat, S. (2015). Determination of colchicine contents in different Jordanian Colchicum spp. Jordan Journal of Pharmaceutical Sciences, 8(2).
[14] Abdulbaqi, I. M., Darwis, Y. U., Khan, N. A., Assi, R. A., & Loh, G. O. (2017). A simple HPLC–UV method for the quantification of colchicine in bulk and ethosomal gel nano-formulation and its validation. International Journal of Pharmacy and Pharmaceutical Sciences, 9(7), 72–78.
[15] Joshi, S. A., Jalalpure, S. S., Kempwade, A. A., & Peram, M. R. (2018). Development and validation of HPLC method to determine colchicine in pharmaceutical formulations and its application for analysis of solid lipid nanoparticles. Current Pharmaceutical Analysis, 14(1), 76–83.
[16] Rajasree, B., & Mukthinuthalapati, M. A. (2019). Analytical methods for the determination of anti-gout drugs. Acta Scientific Pharmaceutical Sciences, 3(4).
[17] Aboul Kasim, E. (2002). Voltammetric behavior of the anti-inflammatory alkaloid colchicine at a glassy carbon electrode and a hanging mercury electrode and its determination at ppb levels. Analytical Letters, 35(12), 1987–2004.
[18] Zhang, H. (2006). Electrochemistry and voltammetric determination of colchicine using an acetylene black-dihexadecyl hydrogen phosphate composite film modified glassy carbon electrode. Bioelectrochemistry, 68(2), 197–201.
[19] Bodoki, E., Săndulescu, R., & Roman, L. (2007). Method validation in quantitative electrochemical analysis of colchicine using glassy carbon electrode. Open Chemistry, 5(3), 766–778.
[20] Bodoki, E., Laschi, S., Palchetti, I., Săndulescu, R., & Mascini, M. (2008). Electrochemical behavior of colchicine using graphite-based screen-printed electrodes. Talanta, 76(2), 288–294.
[21] Wang, F., Zhou, J., Liu, Y., Wu, S., Song, G., & Ye, B. (2011). Electrochemical oxidation behavior of colchicine on a graphene oxide-Nafion composite film modified glassy carbon electrode. Analyst, 136(19), 3943–3949.
[22] Bodoki, E., Vlase, L., & Săndulescu, R. (2015). Mechanistic study of colchicine's reduction behavior. Electrochemistry Communications, 56, 51–55.
[23] Stanković, D. M., Švorc, Ľ., Mariano, J. F., Ortner, A., & Kalcher, K. (2017). Electrochemical determination of natural drug colchicine in pharmaceuticals and human serum sample and its interaction with DNA. Electroanalysis, 29(10), 2276–2281.
[24] Moreira, D. A., Oliveira, F. M., Pimentel, D. M., Guedes, T. J., Luz, R., Damos, F. S., Pereira, A. C., da Silva, R. A., & dos Santos, W. T. (2018). Determination of colchicine in pharmaceutical formulations and urine by multiple-pulse amperometric detection in an FIA system using boron-doped diamond electrode. Journal of the Brazilian Chemical Society, 29(9), 1796–1802.
[25] Fawzy, A., El Guesmi, N., Ali, H. M., & Abdallah, M. (2018). Oxidation of tryptophan by permanganate ion in acid, neutral and alkaline media: A comparative kinetic and mechanistic study.
[26] Singh, D., Srivastava, B., & Sahu, U. A. (2004). Spectrophotometric determination of colchicine using iron (III) chloride and 1,10-phenanthroline. Journal of the Indian Chemical Society, 81(2), 171–173.
[27] Patial, A., & Verma, P. (2012). Development of UV spectrophotometric method for estimation of colchicine in phosphate buffer saline pH 6.4. International Research Journal of Pharmacy, 3, 87–89.
[28] Daneshfar, A., Ansari, F., & Hasanvandi, S. (2012). Spectrophotometric determination of colchicine by phase transfer catalyst. Oriental Journal of Chemistry, 28(1), 89.
[29] Sravya, A., S. P. A., Abdul Sadaf, Ravi Teja Reddy, A., Sireesha, D., & Vaudha Bakshi. (2019). Development and validation of UV spectrophotometric method for estimation of colchicine in bulk and pharmaceutical dosage forms. World Journal of Pharmaceutical Research, 8(3), 933–938.
[30] Fawzy, A., Ashour, S., & Musleh, M. (2014). Kinetics and mechanism of oxidation of L-histidine by permanganate ions in sulfuric acid medium. International Journal of Chemical Kinetics, 46(7), 370–381.
[31] Jain, A., Tazwar, G., & Devra, V. (2017). Kinetics and mechanism of permanganate oxidation of nalidixic acid in aqueous alkaline medium. Journal of Applied Pharmaceutical Science, 7(01), 135–143.
[32] Miller, J. C., & Miller, J. N. (1988). Basic statistical methods for analytical chemistry. Part I. Statistics of repeated measurements. A review. Analyst, 113(9), 1351–1356.
[33] Rahman, N., Khan, N., & Azmi, S. (2004). Kinetic spectrophotometric method for the determination of silymarin in pharmaceutical formulations using potassium permanganate as oxidant. Die Pharmazie – An International Journal of Pharmaceutical Sciences, 59(2), 112–116.
[34] Fawzy, A., Zaafarany, I. A., Tirkistani, F. A., & Asghar, B. H. (2016). Oxidative degradation of atropine drug by permanganate ion in perchloric and sulfuric acid solutions: A comparative kinetic study. Advances in Biochemistry, 4(5), 58–65.
[35] Simandi, L. I., Jaky, M., Savage, C. R., & Schelly, Z. A. (1985). Kinetics and mechanism of the permanganate ion oxidation of sulfite in alkaline solutions. The nature of short-lived intermediates. Journal of the American Chemical Society, 107(14), 4220–4224.
Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
In a brief statement, the rights relate to the publication and distribution of research published in the journal of the University of Sebha where authors who have published their articles in the journal of the university of Sebha should how they can use or distribute their articles. They reserve all their rights to the published works, such as (but not limited to) the following rights:
- Copyright and other property rights related to the article, such as patent rights.
- Research published in the journal of the University of Sebha and used in its future works, including lectures and books, the right to reproduce articles for their own purposes, and the right to self-archive their articles.
- The right to enter a separate article, or for a non-exclusive distribution of their article with an acknowledgment of its initial publication in the journal of Sebha University.
Privacy Statement The names and e-mail addresses entered on the Sabha University Journal site will be used for the aforementioned purposes only and for which they were used.