Oral and Skin Pigmentations associated with hydroxyurea therapeutic doses in a patient with sickle cell disease: Case Report

Aesa Alzaroug Jaber; Almahdi. A. Jaber; Alshame M.J. Alshame

doi:10.51984/joms.v18i1.2606

Oral and Skin Pigmentations associated with hydroxyurea therapeutic doses in a patient with sickle cell disease: Case Report

Authors

Aesa Alzaroug Jaber Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.
Almahdi. A. Jaber Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Tripoli University, Libya.
Alshame M.J. Alshame Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.

DOI:

https://doi.org/10.51984/joms.v18i1.2606

Keywords:

Sickle cell Disease, Hydroxyurea, Hyperpigmentation, Oral Cavity

Abstract

Hydroxyurea is an effective treatment for Sickle cell disease. Hydroxyurea has classified as an antineoplastic agent and is also prescribed as Antisickling agent; it works through inhibition of DNA synthesis at S phase. Despite Hydroxyurea benefits sickle cell patients, undesirable side effect such as leukopenia and hyperpigmentation were observed. Hydroxyurea-induced hyperpigmentation is mainly seen in the skin and rarely in the oral cavity. Although Hydroxyrea-induced pigmentation is benign and reversible, this mild pathological condition should have considered.

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Author Biographies

Aesa Alzaroug Jaber, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.
Almahdi. A. Jaber, Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Tripoli University, Libya.

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Tripoli University, Libya.
Alshame M.J. Alshame, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sebha University, Libya.

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Published

2023-06-05

Issue

Vol. 18 No. 1 (2023): Exploring Diverse Research in Science and Healthcare: Insights from Our Latest Issue

Section

Original Research Article

License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This article is published open access under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0). You may copy, redistribute, adapt and build upon it for non-commercial purposes, provided you credit the authors, cite the original publication in the Journal of Medical Sciences with its DOI, indicate any changes, and distribute any adaptations under the same licence. Copyright rests with the authors. For commercial reuse, please contact the corresponding author. Full terms: https://sebhau.edu.ly/journal/joms/copyright-licensing

How to Cite

Oral and Skin Pigmentations associated with hydroxyurea therapeutic doses in a patient with sickle cell disease: Case Report. J Med Sci (Sebha) [Internet]. 2023 Jun. 5 [cited 2026 Oct. 15];18(1):31-4. Available from: https://www.sebhau.edu.ly/journal/joms/article/view/2606