الأوراق العلمية


عرضالصفحاتعنوان الورقة +الملخصر.م
من 1 ـــ الي 5
الملخص

We report a familial form of combined pituitary hormone deficiency (CPHD) in a Libyan family of a rural area of Fezan region, south Libya. The index case was an 18-year-old, male, secondary school student referred to the medical department at 2nd March Teaching Hospital for assessment of severe growth retardation. Born to a first-degree cousin parent, his height was 109 cm and weight was 20 kg. Hormonal assay revealed CPHD. The familial screening examined the six siblings of the index patient and the parents. Four siblings had a clinical presentation of CPHD. The CPHD phenotype in the present family was characterized by severe dwarfism and a lack of spontaneous puberty. None of the affected patients had blue sclera or limitation of elbow extension described in previous families. All patients had undetectable levels of growth hormone (GH) < 0.2 ng/ml and Luteinizing hormone (LH) < 0.10 mlU/ml. Thyroid hormone levels were below normal in four patients. Corticotroph (ACTH) deficiency was detected in three patients at an early age in contrast to previous reports. Arrangements are underway for genetic screening of the present family for the detective gene. Such genetic screening would prove useful to the clinical management of the affected children since it permits an earlier diagnosis of the hormone of gradual onset, especially thyroid stimulating hormone (TSH) and corticotroph (ACTH) deficiencies. Moreover, it allows anticipating gonadotroph deficiency at pubertal age.

1
من 6 ـــ الي 11
الملخص

Immunoglobulin A Nephropathy (IgA) is the most common primary glomerulonephritis all over the world. The cause of IgA nephropathy is variable, with some patients having stable renal function over decades and others developing nephrotic syndrome, hypertension and progressive renal failure. Most clinicians employ therapy with angiotensin converting enzyme inhibitors or more recently, angiotensin 2 receptor blockers for hypertension and proteinuria. Mycophenolate mofetil (MMF) is increasingly used to treat primary glomerulopathies but there are limited data concerning the efficacy of Mycophenolate mofetil in the primary treatment of progressive IgA nephropathy. Its effectiveness and safety in IgA nephropathy has been evaluated in four major trials, prospective placebo-controlled randomized trials, which have produced conflicting results. The conflicting results range from a reduction in proteinuria towards a worse outcome in mycophenolate mofetil group.

2
من 12 ـــ الي 15
3
من 16 ـــ الي 27
الملخص

The aim of this study was to collect and identify fresh isolates of Gram-positive anaerobic cocci (GPAC) from clinical materials as a basis for the study of taxonomy of GPAC. A total of 116 strains of GPAC, isolated from clinical materials collected from the Department of Microbiology, in St. Lukes Hospital, Guilford and St. Thomas Hospital, London, were investigated. The reference strains were obtained from the American Type Culture Collection (ATCC), Virginia Polytechnic Institute and State University (VPI) and the National Collection of Industrial Bacteria (NCIB). GPAC were identified on the basis of morphology, biochemical examination and the detection of the end products from the fermentation in peptone yeast extract glucose or chopped meat glucose media by means of Gas Liquid Chromatography (GLC). All of the strains studied were obligately anaerobic Gram-positive cocci (GPAC). They occurred in singles, pairs, tetrads, short or long chains. Peptone yeast extract without addition of carbohydrate supported their growth. The strains grew at 37?C. The G.L.C. profiles showed that all strains produced acetic acid and lactic acid. One hundred and three (89%) out of 116 isolates were considered to be different from each other at the species level. These were Peptostreptococcus (Pst.) anaerobius (26.7%), Peptococcus (Pc.) magnus (19%), Streptococcus (Str.) asaccharolyticus (6.9%), Peptostreptococcus (Pst.) micros (3.5%), Peptococcus (Pc.) asaccharolyticus (2.6%), Gaffkya (G.) anaerobia (1.7%), and Megosphaera (M.) elsdenni (0.9%). Thirteen (11.1%) out of 116 strains could not be speciated.

4
من 28 ـــ الي 33
الملخص

An attempt was made to classify gram-positive anaerobic cocci (GPAC) on the basis of their production of fatty acids from the fermentation of mannose, galactose and rhamnose by the use of gas liquid chromatography (GLC). The only species that could be separated were Peptostreptococcus (Pst.) anaerobius and Megasphaera (M.) elsdenii. Unfortunately the other species were indistinguishable using information obtained from the GLC analysis.

5
من 34 ـــ الي 45
الملخص

Malignant chest wall tumors typically manifest as large, poorly marginated infiltrative masses and are more likely than benign tumors to be symptomatic. Although most malignant tumors have a nonspecific imaging appearance, findings such as chondroid or osteoid matrix, combined fat and soft tissue components or diffuse osteolytic change in association with a soft-tissue rib mass can be helpful in suggesting diagnosis of chondrosarcoma or osteosarcoma, liposarcoma, or multiple myeloma respectively. Changes in benign lesions such as the development of a soft tissue mass in association with pre-existing osteochondroma or the loss of a target like appearance in neurofibroma may be early indications of malignant transformation. In some patients, the combined clinical and imaging findings may suggest the diagnosis. For example, findings of chronic lymphedoema may lead to a diagnosis of angiosarcoma, or findings of a large mass with relatively minor rib involvement in a child may indicate a diagnosis of Ewing sarcoma. Even when the findings are nonspecific, imaging is important for tumor staging, therapeutic planning, and follow up of patients with malignant chest wall tumors. However, many chest wall tumors have nonspecific imaging features, and histological analysis of tissue specimens is frequently required for diagnosis. Even after the decision has been made to perform a biopsy, imaging continues to play an important role in tumor management and is frequently used to facilitate biopsy, assess post procedural complications, and perform follow-up evaluation of tumors that are not excised.

6
من 46 ـــ الي 49
7
من 50 ـــ الي 56
الملخص

The present study evaluated the correlation between renin-angiotensin system (RAS) and anxiety in adult male albino mice using elevated plus-maze (EPM). Angiotensin-converting enzyme (ACE) inhibitor captopril (CPL), angiotensin II (ANG II) receptor antagonist losartan (LRN), and anxiolytic drug diazepam (DZP) were used to examine the role of RAS in the central nervous system (CNS). The acute administration of captopril, losartan and diazepam all caused the reduction of anxiety-like behaviour. They also antagonised the anxiety-like behavior caused by withdrawal of chronic administration of diazepam. Losartan showed better effect than captopril in reversing the anxiety-like behaviour, indicating a possible role of angiotensin receptor in the mediation of anxiety. Therefore it may be concluded that renin-angiotensin system may have a role to play in the genesis of anxiety.

8
من 57 ـــ الي 64
الملخص

The antagonistic activity of Lactobacillus delbrueckii against target pathogens such as Escherichia coli, Salmonella Sp. Shigella Sp, Aspergillus niger and Candida albicans was tested. The antagonistic activity of Lactobacillus delbrueckii was compared with Calotropis gigantea extract. Antimicrobial activity of Lactobacillus delbrueckii and Calotropis gigantea was assessed by agar well assay technique. Lactobacillus delbrueckii was inoculated into broth and incubated at 370C for 24 hrs. Cell free extracts were obtained by centrifugation. Wells of 6 mm diameter were made in each plate of Tryptone dextrose agar seeded with test pathogenic organisms. Cell free extract of Lactobacillus delbrueckii cultures were transferred at the rate of 50 ?l into each well. In another well the plant extract was transferred at the rate of 50 ?l. The plates were incubated at 370C for 48 hours without inverting. Zones of inhibition formed around the well were measured.

9
من 65 ـــ الي 70
10
من 71 ـــ الي 77
11
من 78 ـــ الي 85
الملخص

The furcation is an area of complex anatomy and its involvement complicates treatment planning and the performance of therapeutic procedures, and directly affects the ability of both the patient and therapist to successfully maintain the dentition after active treatment. A thorough knowledge of the anatomy of the furcation is as essential to successful treatment as a mastery of the various methods of furcation therapy. This study aims to determine the bucco- lingual measurements of the root at the level of cemento-enamel junction and the mesial and distal roots at the level of root separation. One hundred extracted permanent human mandibular molars which consisted of 50 first mandibular molar and 50 second mandibular molar were used in the study. The width of the teeth is recorded at four points, at the center of cemento enamel junction entrance, the width of the furcation roof at the point of separation of the mesial and distal roots and the maximum width of the mesial and distal roots at the level of furcation entrance. The results showed that the width at the entrance of the furcation has a mean of 6.54 ? 0.60mm in first molars and 5.94 ? 0.71 in second molars. The results of this study suggest that 4.45 to 7.90 mm of horizontal attachment loss in the interradicular periodontium may result in communication between the buccal and lingual furcation entrances.

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